Period–amplitude co‐variation in biomolecular oscillators

Period-Amplitude Co-variation in Biomolecular Oscillators

The period and amplitude of biomolecular oscillators are functionally important properties in multiple contexts. For a biomolecular oscillator, the overall constraints in how tuning of amplitude affects period, and vice versa, are generally unclear. Here we investigate this co-variation of the period and amplitude in mathematical models of biomolecular oscillators using both simulations and ana...

Deterministic characterization of phase noise in biomolecular oscillators.

On top of the many external perturbations, cellular oscillators also face intrinsic perturbations due the randomness of chemical kinetics. Biomolecular oscillators, distinct in their parameter sets or distinct in their architecture, show different resilience with respect to such intrinsic perturbations. Assessing this resilience can be done by ensemble stochastic simulations. These are computat...

Dynamical response of nanomechanical oscillators in immiscible viscous fluid for in vitro biomolecular recognition.

Dynamical response of nanomechanical cantilever structures immersed in a viscous fluid is important to in vitro single-molecule force spectroscopy, biomolecular recognition of disease-specific proteins, and the study of microscopic protein dynamics. Here we study the stochastic response of biofunctionalized nanomechanical cantilever beams in a viscous fluid. Using the fluctuation-dissipation th...

Beyond Covariation 1 Beyond covariation: Cues to causal structure

Covariation in natural causal induction.

The covariation component of everyday causal inference has been depicted, in both cognitive and social psychology as well as in philosophy, as heterogeneous and prone to biases. The models and biases discussed in these domains are analyzed with respect to focal sets: contextually determined sets of events over which covariation is computed. Moreover, these models are compared to our probabilist...